Leczenie depresji ziołową terapią biologiczną (układ hormonalny) cz.2

Oś podwzgórze-przysadka-nadnercza HPA  jest  to złożony zestaw interakcji pomiędzy podwzgórzem (część mózgu), przysadką (część mózgu) i nadnerczem (górna część nerki).  Oś HPA pomaga regulować bardzo wiele Depresja funkcji naszego organizmu takich jak  temperatura ciała, procesy trawienia, układ odpornościowy, funkcje seksualne oraz nastrój. Nadmierna aktywacja osi HPA w wyniku nadmiernej produkcji hormonów stresu takich jak kortyzol może być przyczyną wielu chorób psychicznych w tym depresji . Zioła skutecznie  regulują oraz normalizują zaburzenia osi również w ciężkich przypadkach depresji.

Rośliny oddziaływujące na układ hormonalny (poprawa dysfunkcji HPA ):

a) Olejek różany z Róży damasceńskiej (Rosa  damascena Mill.) – inhalacja olejkiem hamuje aktywację indukowanej stresem osi HPA, a tym samym zapobiega przewlekłemu stresowi który prowadzi do depresji [1]. Inhalacje olejkiem trzy razy dziennie .

róża damasceńska

b)  Pluskwica groniasta (Cimicifuga racemosa) – hamuje nadmierną aktywnoś ośi HPA [2] . Ekstrakt na etanolu 50% .Dawkowanie  3 ml 3 razy dziennie co 8 godzin.

Roślina

c) Krzyżownica(Polygala tenuifolia) – blokuje podwyższony poziom kortyzolu w osoczu który jest wskaźnikiem wysokiej aktywności osi podwzgórze-przysadka-nadnercza (HPA) , jest również inhibitorem monoaminooksydazy  MAO-A  oraz MAO-B  [3] . Ekstrakt na etanolu 50% 1:5 . Dawkowanie 5ml 3 razy dziennie co 8 godzin.

Krzyżownica

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Bibliografia

[1]   
Chem Senses. 2012 May;37(4):347-56. doi: 10.1093/chemse/bjr108. Epub 2011 Dec 13.
Effect of „rose essential oil” inhalation on stress-induced skin-barrier disruption in rats and humans.
Fukada M, Kano E, Miyoshi M, Komaki R, Watanabe T.
SourceDivision of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine, Yonago, Tottori 683, Japan.
Abstract
In stressed animals, several brain regions (e.g., hypothalamic paraventricular nucleus [PVN]) exhibit neuronal activation, which increases plasma adrenocorticotropic hormone (ACTH) and glucocorticoids. We previously reported that so-called „green odor” inhibits stress-induced activation of the hypothalamo-pituitary-adrenocortical axis (HPA axis) and thereby prevents the chronic stress-induced disruption of the skin barrier. Here, we investigated whether rose essential oil, another sedative odorant, inhibits the stress-induced 1) increases in PVN neuronal activity in rats and plasma glucocorticoids (corticosterone [CORT] in rats and cortisol in humans) and 2) skin-barrier disruption in rats and humans. The results showed that in rats subjected to acute restraint stress, rose essential oil inhalation significantly inhibited the increase in plasma CORT and reduced the increases in the number of c-Fos-positive cells in PVN. Inhalation of rose essential oil significantly inhibited the following effects of chronic stress: 1) the elevation of transepidermal water loss (TEWL), an index of the disruption of skin-barrier function, in both rats and humans and 2) the increase in the salivary concentration of cortisol in humans. These results suggest that in rats and humans, chronic stress-induced disruption of the skin barrier can be limited or prevented by rose essential oil inhalation, possibly through its inhibitory effect on the HPA axis.

[2]
Biomed Res. 2012 Apr;33(2):133-7.
Oral administration of Cimicifuga racemosa extract affects immobilization stress-induced changes in murine cerebral monoamine metabolism.
Nadaoka I, Yasue M, Sami M, Kitagawa Y.
SourceResearch Laboratories for Fundamental Technology of Food, Asahi Group Holdings, Ltd., 1-21, Midori 1-Chome, Moriya-shi, Ibaraki, 302-0106, Japan. nadaokai@wakodo.co.jp
Abstract
We investigated the effects of Cimicifuga racemosa (CR) plant extracts on the changes in levels of the cerebral monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT), the respective metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA), and plasma corticosterone in mice subjected to acute immobilization stress. Single oral administration of the CR extract (1,000 mg/kg) significantly attenuated plasma corticosterone levels that had been increased as a result of enforced immobilization. Acute immobilization stress caused significant changes in the corresponding amine-to-metabolite ratios in the hypothalamus, hippocampus, and cortex; however, CR-extract treatment significantly attenuated the MHPG/NE change in the hypothalamus, and the 5-HIAA/5- HT changes in each region of the brain. Our results suggest that the CR extract interacts not only with the hypothalamic-pituitary-adrenal (HPA) axis but also with the sympathetic adrenomedullary (SAM) system under stress conditions. Thus the CR extract can alleviate acute stress responses by suppressing the changes of amine-to-metabolite ratio in brain.

[3]
J Pharm Pharmacol. 2011 Jun;63(6):869-74. doi: 10.1111/j.2042-7158.2011.01281.x. Epub 2011 May 3.
Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd.
Hu Y, Liu M, Liu P, Guo DH, Wei RB, Rahman K.
SourceDepartment of Clinical Pharmacology and Pharmacy, Center of Pharmacy, Chinese PLA General Hospital, Beijing, China.
Abstract
OBJECTIVE: The present study was designed to observe the effects of 3,6′-disinapoyl sucrose (DISS), an active oligosaccharide ester component obtained from the roots of Polygala tenuifolia Willd., on behavioral and biochemical aspects of depression induced by chronic mild stress (CMS) in rats. It is the first exploration of the possible association between DISS’s antidepressant-like effects and biochemical markers of depression, and involved measuring monoamine oxidase (MAO) activity, cortisol levels, superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels.
METHODS: Rats were exposed to stressor once daily for consecutive 5 weeks. DISS and a positive control drug, fluoxetine, were administered via gastric intubation to once daily for consecutive 3 weeks from the third week.
KEY FINDINGS: The results showed that rats subjected to CMS exhibit a reduction in sucrose intake. Conversely, brain MAO-A and MAO-B activity, plasma cortisol levels, and MDA levels were increased, while SOD activity was decreased following CMS exposures. DISS significantly inhibited MAO-A and MAO-B activity and blocked plasma elevated cortisol level, an indicator of the hypothalamic-pituitary-adrenal (HPA) axis. In addition, DISS increases SOD activity, inhibits lipid peroxidation, and lessens production of MDA.
CONCLUSION: These results suggest that DISS may possess potent and rapid antidepressant properties, which are mediated via MAO, the HPA axis and oxidative systems. These antidepressant actions make DISS a potentially valuable drug for the treatment of depression.

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